The IAP family: endogenous caspase inhibitors with multiple biological activities
نویسندگان
چکیده
منابع مشابه
Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy.
The IAPs (inhibitor of apoptosis proteins) are a family of caspase inhibitors that block the execution phase of apoptosis. Overexpression of IAPs confers chemoresistance and, in some groups of patients, is associated with a poor prognosis. Given their role in the development and progression of solid tumors and hematologic malignancies, efforts are underway to develop therapeutic IAP inhibitors,...
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متن کاملDiverse functions within the IAP family.
Inhibitors of apoptosis (IAPs) are a diverse group of signaling molecules that function in a wide range of cellular roles, from the inhibition of caspases to the promotion of cell-cycle progression. These diverse functions may well be linked to the many different domains that are contained within different proteins in the family. IAP family members were first described as inhibitors of apoptosi...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2000
ISSN: 1001-0602,1748-7838
DOI: 10.1038/sj.cr.7290046